APPLICATIONS
A few of our unique applications using On-chip Sort
ADVANTAGES
Some benefits in using the world's first microfluidic cell sorter
PRODUCTS
On-chip Biotechnologies' product lineup
SORTING TECHNOLOGY
Our unique sorting technique explained
NEWS/EVENTS
News and upcoming events
COMPANY
About our companyAPPLICATIONS
A few of our unique applications using On-chip Sort. We have users in various fields of research.
EXTENDING YOUR RESEARCH WITH ON-CHIP SORT
This microfluidic chip cell sorter has allowed users to do what they could not do before. Now you have a tool to make your brilliant ideas come to life!
STEM CELL RESEARCH
iPSCs, iPSC-derived cells and stem cells can be sorted without damaging the cells. Sorting in aseptic condition while preventing cross-contamination will greatly benefit research in cell transplantation.
CELL CLUSTERS & ORGANOIDS
Cell clusters, such as spheroids and organoids of diameter up to 150μm can be sorted while keeping the shape intact. Primary cell clumps and small organisms are also be sorted.
RARE CELL SORTING (CTC)
Rare cells (<0.01%) can be collected efficiently using our multi-step sorting technique. For example, Circulating Tumor Cells (CTCs) can be collected efficiently in an hour after sample pre-treatment.
EMULSION DROPLETS
Water-in-oil emulsion droplets can be sorted using oil as sheath fluid. Those droplets are used as a way to compartmentalize a sample, and reactions and cultivation of microbes ca be carried out in each individual droplet.
CELL CULTURING
Fragile cells sorted using conventional method show slow or no growth due to sorting damage. Improved cell viability and growth rate are observed for cells collected using our gentle sorting techniques.
ENVIRONMENTAL MICROORGANISMS
Microorganisms, such as soil microbes and marine organisms, are often susceptible to the sorting conditions. On-chip Sort allows for the use of any liquid as sheath fluid.
| Neurons | Sperms cells | Cardiomyocytes |
| Phytoplanktons | Plant cells | Hepatocytes |
| Yeasts | Gel balls | Pollen |
PRODUCT
On-chip Biotechnologies currently offer two instruments: On-chip Sort (cell sorter) and On-chip SPiS (single cell dispenser)
Droplet selector and single droplet plater
“On-chip® Droplet Selector”
Cell/microorganism screening at 1,000 times higher throughput than conventional screening methods.
Microfluidic chip cell sorter
“On-chip® Sort”
Revolutionary cell sorter using disposable microfluidic chip for damage-free and sterile sorting.
Single cell/particle dispenser
“On-chip SPiS”
Accurate and gentle cell/particle dispenser for single cell/particle plating into 96- or 384-well plate.
Monodisperse droplet generator
“On-chip Droplet Generator”
Stable and uniform production of emulsion droplets. Using our unique microfluidic chip, stable and uniform droplets can be produced.
SORTING TECHNOLOGY
Jet-in-air or Cuvette hybrid cell sorters have multiple processes that triggers sorter-induced cellular stress (SICS). On-chip Sort allows for much gentler sorting of cells compared to conventional sorters because the use of microfluidic chip has eliminated such damaging steps.
| Conventional Sorter | On-chip Sort | |
|---|---|---|
| Sorting Pressure | Approx. 40psi | Approx. 0.3psi |
| High-speed Collision | Cells collide at high-speed when collected | No collision |
| Electrostatic Charging | Cells are stressed due to charging | No electrostatic charging |
| Aerosol Generation | Potentially hazardous for users | No aerosols |
| Sorting Medium | Must use specified sorting medium | Most standard media accepted |
| Washing | Post-sort wash with harsh chemicals | No post-sort washing |
NEWS/EVENT
Latest information on updates, upcoming events and press-releases
On-chip has established a U.S. office!On-chip Biotechnologies Co., Ltd. has established a U.S. office in Massachuset[...]
NOVEMBER 10, 2023
The 11th World Congress and Expo on Applied MicrobiologyWe are going to have a virtual booth, at The 11th World Congress and Expo on A[...]
OCTOBER 24, 2023
RAFT®15We are going to attend RAFT 15 on October 29 – November 1, 2023 Please c[...]
OCTOBER 24, 2023
